Identification of Arhgef12 and Prkci as Genetic Modifiers of Retinal Dysplasia in the Crb1rd8 Mouse Model
Sonia M. Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa V. Stone, Nattaya Damkham, Lillian F. Hyde, James G. Peterson, Wanda L. Hicks, Gregory W. Carter, Jürgen Κ. Naggert, Mark P. Krebs, Patsy M. Nishina
This study identifies Arhgef12 and Prkci as genetic modifiers that influence the severity of retinal dysplasia in the Crb1rd8 mouse model, revealing differential disease progression and cellular mislocalization.
PLoS Genetics · Jun 8, 2022Peer-reviewedGenetics