Patsy M. Nishina

The paper uses single-cell RNA sequencing to analyze RPE cell heterogeneity in mice, identifying six cell populations and changes in gene expression during maturation.

This study identifies Arhgef12 and Prkci as genetic modifiers that influence the severity of retinal dysplasia in the Crb1rd8 mouse model, revealing differential disease progression and cellular mislocalization.

The paper quantifies age-related changes in axial and retinal biometry in hyperopic mouse models and identifies strain-specific differences in ocular growth.

This study shows that Lyst deficiency in mice leads to retinal detachment by causing phagosome accumulation and increased proteases in retinal pigment epithelial cells.