Jürgen Κ. Naggert

This paper creates a mouse model with the ARMS2A69S variant to study AMD, finding it causes mitochondrial dysfunction and AMD-like phenotypes.

The paper uses single-cell RNA sequencing to analyze RPE cell heterogeneity in mice, identifying six cell populations and changes in gene expression during maturation.

This study identifies Arhgef12 and Prkci as genetic modifiers that influence the severity of retinal dysplasia in the Crb1rd8 mouse model, revealing differential disease progression and cellular mislocalization.

This study shows that Lyst deficiency in mice leads to retinal detachment by causing phagosome accumulation and increased proteases in retinal pigment epithelial cells.