Graph-based tracing of dynamically functioning gene circuits in cell fate decisions with isoform resolution
Wanqi Li, Hao Dong, Zihan Zhou, Wenlin Fan, Yutong Zhou, Xiaochun Yang, Gang Xue, Zhiyuan Li
The paper introduces TFA (Transcription Factor Activity) to infer TF-TF interactions with high fidelity, outperforming expression-based methods and revealing isoform-level heterogeneity in regulatory circuits.
bioRxiv · Oct 21, 2025 · PreprintSystems Biology