Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
Ashley P Ng, Maria Kauppi, Donald Metcalf, Craig D Hyland, Emma C Josefsson, Marion Lebois, Jian-Guo Zhang, Ladina Di Rago, Tracey Baldwin, Douglas J Hilton, Warren S Alexander
This study shows Mpl expression on megakaryocytes and platelets is not needed for platelet production but is essential to prevent myeloproliferation by controlling TPO availability.
bioRxiv · Mar 19, 2014Cell Biology