Programmed electrical stimulation in human iPSC-derived cardiomyocytes reveals mechanisms of lethal arrhythmias in Calcium Release Deficiency Syndrome
Saif Dababneh, Alia Arslanova, Mariam Butt, Torin Halvorson, Thomas M. Roston, Jason D. Roberts, Seiko Ohno, Farah Jayousi, Philipp F. Lange, Leif Hove‐Madsen, Robert Alan Rose, Edwin D.W. Moore, Filip Van Petegem, Shubhayan Sanatani, Wayne S. R. Chen, , Maksymilian Prondzynski
This study uses hiPSC-derived cardiomyocytes to model CRDS, showing that programmed electrical stimulation induces arrhythmias through EADs and re-entry, which can be suppressed by flecainide.
bioRxiv · Apr 13, 2026 · PreprintCell Biology