Glen F. Tibbits

Conservation and divergence of transcriptional heterogeneity in the cardiac conduction system

This study compares transcriptional heterogeneity in the cardiac conduction system across species and developmental stages using single-cell and spatial transcriptomic data.

Programmed electrical stimulation in human iPSC-derived cardiomyocytes reveals mechanisms of lethal arrhythmias in Calcium Release Deficiency Syndrome

This study uses hiPSC-derived cardiomyocytes to model CRDS, showing that programmed electrical stimulation induces arrhythmias through EADs and re-entry, which can be suppressed by flecainide.

Sex- and ketogenesis-dependent effects of intermittent fasting against diet-induced obesity and fatty liver disease

This study shows that intermittent fasting improves systemic metabolism regardless of ketogenesis but has sex-specific hepatic benefits requiring ketogenesis in mice.

Molecular Rewiring in TNNT2-Linked Hypertrophic Cardiomyopathy hiPSC-Derived Cardiomyocytes upon Metabolic Maturation

This study investigates how metabolic maturation affects molecular and metabolic states in hiPSC-derived cardiomyocytes with TNNT2-linked hypertrophic cardiomyopathy, revealing variant-specific disruptions in metabolic pathways and gene regulation.

Developing a Soft Micropatterned Substrate to Enhance Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)

This paper develops a micropatterned substrate to enhance maturation of hiPSC-CMs, finding optimal maturation occurs at three weeks on a soft PDMS substrate.