Mitochondrial uncoupler BAM15 improves skeletal muscle function and mitochondrial respiration in Sarcopenia
Dean G. Campelj, Ashleigh M. Philp, Elya J. Ritenis, Camila S. Padilha, Isabelle Alldritt, James Sligar, Tabitha Cree, Stephanie J. Alexopoulos, Webster. L Santos, Sophie Joanisse, Paul M. Coen, Kyle L. Hoehn, Andrew Philp
This study shows that BAM15 improves mitochondrial efficiency and contractile function in aged male mice but not females, suggesting sex-specific effects in sarcopenia.
bioRxiv · Oct 30, 2025 · PreprintPhysiology