Andrew Philp

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

This study shows that ageing reduces the phospho-proteomic response to resistance exercise in human skeletal muscle, despite normal mTORC1 activation, suggesting new therapeutic targets for aged muscle.

This study shows that exercise training restores mitochondrial quality control in sarcopenic muscle by improving mitophagy, mitochondrial respiration, and muscle strength.

This study shows that BAM15 improves mitochondrial efficiency and contractile function in aged male mice but not females, suggesting sex-specific effects in sarcopenia.

This study shows that lean, healthy older men maintain anabolic sensitivity to amino acids and exercise, with increased mTORC1 signaling and muscle protein synthesis, suggesting aging alone does not cause anabolic resistance.