Beyond Lipschitz: Ranking Binding Affinity in Hyperbolic Space
Kelin Wu, Xin Hong, Wenyu Zhu, Bowen Gao, Wei-Ying Ma, Yanyan Lan
This paper introduces AlphaRank, a deep learning model that ranks protein-ligand binding affinity using hyperbolic geometry to overcome limitations of Euclidean space models.
bioRxiv · Feb 3, 2026 · PreprintBioinformatics