Xin Hong

GalaxyVS rapidly screens 100 billion compounds against protein structures, achieving high throughput and releasing a cross-species interaction database.

This paper introduces AlphaRank, a deep learning model that ranks protein-ligand binding affinity using hyperbolic geometry to overcome limitations of Euclidean space models.

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.

This study identifies CDCA7 as a hemimethylated DNA sensor that interacts with HELLS to facilitate nucleosome remodeling and DNA methylation maintenance.