Sp100-HMG drives 'inside-out' PML-NB assembly to modulate transcription and cell-cycle dynamics
Hongchang Dong, Xiuyan Guo, Yilei Ma, Chaoyi Chen, Jialing Li, Xiaoli Zhang, Weidong Li, Xiaomei Deng, Honghui Lai, Yaotong Liao, Lin Ye, Pei Xu
This study identifies Sp100-HMG as a master liquid nucleator that drives 'inside-out' PML-NB assembly, modulating transcription and cell-cycle dynamics through hierarchical condensation.
bioRxiv · Jul 28, 2025 · PreprintCell Biology