Xin Gao

Reinforcement learning with evolutionary priors unlocks multi-site enzyme optimization from sparse experimental feedback

AlphaVariant uses reinforcement learning with evolutionary priors to optimize enzyme variants from sparse experimental data, achieving high activity improvements in multiple rounds of optimization.

A Fkh1/2 binding site array in the WHI5 promoter drives sub-scaling transcription

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

Multi-omic characterization of allele-specific regulatory variation in hybrid pigs

This study characterizes allele-specific regulatory variation in hybrid pigs using multi-omic data across tissues and developmental stages, identifying genes influenced by parent-of-origin and genotype effects.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

A hybrid unsupervised approach for accurate short read clustering and barcoded sample demultiplexing in nanopore sequencing

This paper introduces a hybrid unsupervised method for accurate short read clustering and barcoded sample demultiplexing in nanopore sequencing, outperforming traditional tools in clustering and matching learning-based methods in demultiplexing.

Computational Model for Simulating Drug-Induced Arrhythmia Sensitivity of Human iPSC-derived Cardiomyocytes

The paper develops a computational model of hiPSC-derived cardiomyocytes to simulate drug-induced arrhythmia sensitivity, incorporating differences in ion channel expression compared to adult cardiomyocytes.