A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease
Sarah Jane Miller, Hua Zhong, Weidong Wu, Audrey M. Cordova, Morgan E. Yashchenko, Alex Yashchenko, Zhang Li, Daniyal J. Jafree, Chelsea N. Zimmerman, Christa I. DeVette, Vicki Do, Maya Hignite, Yohan Park, Fariha Nusrat, Dr Bibi Maryam, , Kurt A. Zimmerman
This study constructs a cross-model spatial and single-cell atlas of PKD, identifying Spp1 (osteopontin) as a conserved driver of disease progression through its signaling to Ly6clo monocytes.
JCI Insight · Jul 28, 2026Peer-reviewedBioinformatics