Bradley K. Yoder

This paper develops a collagen-targeting MRI contrast agent to noninvasively detect early fibrosis in ADPKD, showing improved detection compared to standard agents.

This study constructs a cross-model spatial and single-cell atlas of PKD, identifying Spp1 (osteopontin) as a conserved driver of disease progression through its signaling to Ly6clo monocytes.

This paper describes the generation of zebrafish models carrying specific human disease variants using CRISPR/Cas9 and ssODNs, with methods to evaluate HDR efficiency and genotype F1 animals.

The paper identifies drug targets and repurposing candidates for ADPKD by analyzing gene expression signatures from mouse Pkd2 models using signature reversion.

This study shows that Atxn10 is essential for embryonic heart development and adult kidney and pancreas function, with loss leading to lethality and epithelial to mesenchymal transition.

The paper identifies an evolutionarily conserved genetic interaction between nphp-4 and bbs-5 mutations that exacerbates ciliopathy phenotypes across C. elegans, zebrafish, and mice.

This study creates Bbs5 mouse models to investigate ciliary function, revealing developmental origins of specific BBS phenotypes like pituitary anomalies and infertility.