Application of Engineered NK-92 Cell Extracellular Vesicles in the Treatment of Systemic Lupus Erythematosus
Yu Sun, Zeyu Tang, Mengting Guo, Zimeng Zhai, Zixian Wu, Xia Wang, Feng Li, Weiling An, Xiaowei Dou
This study develops engineered NK-92 cell-derived extracellular vesicles targeting CD19 to treat SLE in mice, showing reduced B cells, improved renal function, and increased survival.
bioRxiv · Apr 15, 2026 · PreprintSynthetic Biology