Quantitative Calibration of a Spatial QSP Model Identifies Fibroblast Impact on HCC Immunotherapy
Shuming Zhang, Hanwen Wang, Yeonju Cho, Heber Lima da Rocha, Wendy Wong, Mark M. Yarchoan, Elizabeth M. Jaffee, Won Jin Ho, Luciane Tsukamoto Kagohara, Elana Judith Fertig, Aleksander S. Popel, Atul M. Deshpande
The paper calibrates a spatial QSP model using CODEX data to predict TME states and identify biomarkers for HCC immunotherapy response.
Proceedings of the National Academy of Sciences · Jul 14, 2026Peer-reviewedBioinformatics