Aleksander S. Popel

This paper develops a QSP model to simulate TROP2-targeted ADC efficacy in TNBC, showing tumor heterogeneity and payload pharmacokinetics drive response.

The paper introduces MAPLE, a framework that uses structured schemas to improve LLM-assisted QSP model calibration by ensuring data provenance and reducing hallucination.

The paper calibrates a spatial QSP model using CODEX data to predict TME states and identify biomarkers for HCC immunotherapy response.

This study evaluates suprachoroidal delivery of AXT107 microparticles for treating retinal and choroidal vascular diseases, showing reduced neovascularization and favorable safety.

The paper identifies NF27, a novel oncolytic peptide that induces immunogenic cancer cell death and eradicates tumors with low toxicity through structure-activity relationship studies.

This study introduces a bi-level graph model to identify prognostic tumor microenvironment patterns in breast cancer, validated across multiple cohorts.

The paper uses virtual patient models to evaluate biomarkers for predicting response to PD-1 blockade in TNBC, finding that early on-treatment biomarkers and blood-based markers offer better performance.

The paper develops a computational model of endothelial cell signaling under hypoxia, showing differences in patterning pathways and the role of Notch signaling in vascular permeability.

The paper identifies spatial and compositional biomarkers in the tumor microenvironment of triple-negative breast cancer that predict clinical outcomes using imaging mass cytometry and deep learning.

The paper uses a QSP model to generate virtual patients for NSCLC and predicts response to PD-L1 inhibition using immunogenomic data.

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.

The paper develops a computational model to predict the role of IL-6 trans-signaling in endothelial cell signaling, showing it dominates over classic signaling in activating key pathways.