Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancer
Pingping Cao, Xiaohui Zhou, Suisui Yang, Tianqi Shen, Shuai Wang, Hanyang Yu, Xiaorong Liu, Yeqing Gong, WenHong Wang, Haiyang Wang, Tingting Zhou, Jing Wang, Zhining Fan, Mingde Huang, Qian Xu, , Fan Lin
This study shows that PIK3CA mutations in colorectal cancer induce senescence and SASP, causing resistance to palbociclib, but combining it with erlotinib overcomes this resistance.
bioRxiv · Nov 15, 2024 · PreprintCancer Biology