PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer
Xiao-Lei Meng, Xiaolin Hu, Shan Gao, Wenrui Jia, Sai Zhang, Siqi Zhang, Xiao Wang, Shumin Ma, Chong Qin
This study develops PSMA-guided PROTACs for prostate cancer, showing they selectively degrade target proteins in PSMA-overexpressing cells and improve therapeutic effects in vivo.
Journal of Medicinal Chemistry · May 2, 2025Peer-reviewedCancer Biology