Phosphorylation-induced flexibility of proto-oncogenic Bcl3 regulates transcriptional activation by NF-κB p52 homodimer
Wenfei Pan, Tapan Biswas, Shandy Shahabi, William Suryajaya, Andres M. Vasquez, Qian Du, Gourisankar Ghosh, Vivien Ya‐Fan Wang
This study shows phosphorylation at Ser366 enhances Bcl3's transcriptional activity by increasing C-terminal flexibility, enabling better DNA binding with p52:p52 complexes, and linking structural changes to cancer-related mutations.
bioRxiv · Jun 30, 2024 · PreprintBiochemistry