Phosphorylation-induced flexibility of proto-oncogenic Bcl3 regulates transcriptional activation by NF-κB p52 homodimer
Wenfei Pan, Tapan Biswas, Shandy Shahabi…·Vivien Ya‐Fan Wang
This study shows phosphorylation at Ser366 enhances Bcl3's transcriptional activity by increasing C-terminal flexibility, enabling better DNA binding with p52:p52 complexes, and linking structural changes to cancer-related mutations.