Mammalian Neuraminidase-1 is a Critical Target of Thromboxane Induced T-Cell Immunosuppression
William W. Harless, Yunfan Li, Myron R. Szewczuk
This paper shows that aspirin and celecoxib inhibit TXA2-induced NEU1 activity and ARHGEF1 expression, explaining their similar clinical efficacy in colorectal cancer.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology