Gut microbiota dysbiosis induced by brain tumor modulates the efficacy of immunotherapy
Hyeon Cheol Kim, Hyun-Jin Kim, Jeongwoo La, Won Hyung Park, Sang Hee Park, Byeong Hoon Kang, Yumin Kim, Heung Kyu Lee
This study shows that gut microbiota dysbiosis caused by brain tumors affects immunotherapy efficacy, and tryptophan supplementation or Duncaniella dubosii colonization can restore microbiota and improve survival.
Cell Reports · Jun 26, 2025Peer-reviewedMicrobiology