Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer.
N. T. Santiappillai, X. C. Kong, M. F. Hakeem-Sanni, M. Ghasemi, A. Withy, L.-E. Quek, A. J. Hoy
This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.
bioRxiv · Mar 25, 2024 · PreprintCancer Biology