M. F. Hakeem-Sanni

Capacity-Contribution Paradox: Fatty Acid Oxidation Compensates for Low Glucose-Derived Acetyl-CoA in Cancer.

This study reveals that fatty acid oxidation (FAO) in cancer cells primarily compensates for low glucose-derived acetyl-CoA by supporting mitochondrial metabolism through a malic enzyme-dependent shunt, rather than serving as a primary fuel source.

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells

The paper identifies distinct glutamine metabolism in a subset of proliferating cells using pathway-centric metabolomic analysis of cancer and non-cancer cell lines.

CPT1a regulates the delivery of extracellular fatty acids for cardiolipin turnover in prostate cancer cells.

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.

Hepatic Lipid Droplet-Associated Proteome Changes Distinguish Dietary-Induced Fatty Liver from Insulin Resistance in Male Mice.

This study identifies distinct lipid droplet proteome changes in mice fed high-fat or high-starch diets compared to chow, linking these changes to fatty liver and glucose tolerance.