The 'C3aR antagonist' SB290157 is a partial C5aR2 agonist
X. X. Li, V. Kumar, J. D. Lee, T. M. Woodruff
This paper reveals that SB290157, previously thought to be a C3aR antagonist, acts as a partial agonist at C5aR2 and has mixed effects on C3aR signaling.
bioRxiv · Aug 1, 2020Pharmacology & Toxicology