Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles
Xuan Xie, Xia Sun, Yuheng Wang, Ben Lehner, Xianghua Li
The paper investigates how mutations interact in diploid organisms, showing that epistasis and dominance are common, context-dependent, and change with system complexity and conditions.
Nature Communications · Sep 9, 2023Peer-reviewedGenetics