Author

Xianghua Li

King's College LondonORCID 0000-0002-2172-7271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:variant effect prediction· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ben LehneriD· 4 shared Huijin WeiiD· 1 shared Jasna Lalić· 1 shared Pablo Baeza-CenturióniD· 1 shared Riddhiman DhariD· 1 shared Xia Sun· 1 shared Xuan XieiD· 1 shared Yuheng WangiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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4 shared papersGenomics

Ben LehnerORCID

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4 papers

Recent·Most cited

Complete Mutagenesis of the Genome and Proteome of {Phi}X174

Huijin Wei, Xianghua Li, Ben Lehner

This paper systematically mutagenizes the genome and proteome of PhiX174, revealing that most mutations impair fitness, with protein interaction disruptions being a major cause.

bioRxiv · Jul 26, 2026 · PreprintGenomics

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins

Xianghua Li, Ben Lehner

The paper introduces TF-MAPS, a platform to map functional and allosteric sites of DNA-binding proteins, showing distance-dependent allostery and druggable pockets in three human TFs.

bioRxiv · Oct 20, 2025 · PreprintGenomics

Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles

Xuan Xie, Xia Sun, Yuheng Wang, Ben Lehner, Xianghua Li

The paper investigates how mutations interact in diploid organisms, showing that epistasis and dominance are common, context-dependent, and change with system complexity and conditions.

Nature Communications · Sep 9, 2023Peer-reviewedGenetics

Changes in gene expression shift and switch genetic interactions

Xianghua Li, Jasna Lalić, Pablo Baeza-Centurión, Riddhiman Dhar, Ben Lehner

The paper shows that changes in gene expression alter the strength and direction of genetic interactions between mutations in many genes.

Nature Communications · Aug 29, 2019Peer-reviewedGenetics