Xuan Xie

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-kB and p53 perturbation

This study shows that persistent LPS exposure in macrophages leads to a unique immunometabolic profile with altered oxygen consumption, ATP levels, and glycolysis, distinct from short-term LPS responses.

Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles

The paper investigates how mutations interact in diploid organisms, showing that epistasis and dominance are common, context-dependent, and change with system complexity and conditions.