Network analysis reveals a distinct axis of macrophage activation in response to conflicting inflammatory cues
Xiaji Liu, Jingyuan Zhang, Angela C. Zeigler, Anders R. Nelson, Merry L. Lindsey, Jeffrey J. Saucerman
The paper develops a computational model of macrophage signaling to predict activation responses to cytokine combinations, revealing a second axis of activation distinct from the M1-M2 polarization.
The Journal of Immunology · Jan 6, 2021Peer-reviewedSystems Biology