Intravenous BCG immunization drives naive CD4+ T cell to Th1 differentiation via CD4+ T cell epigenetic reprogramming
Ruilin Wang, Yuanhui Zhao, Jie An Yang, Renjie Luo, Weikang Sun, Mengyu Zhang, Xiangdong Liu, Yayi Hou, Peng Cao, Erguang Li
This study shows that IV BCG immunization promotes Th1 differentiation of naive CD4+ T cells through epigenetic reprogramming and enhances antiviral activity against RSV.
bioRxiv · May 23, 2025 · PreprintImmunology