Symmetric brain-liver circuits mediate lateralized regulation of hepatic glucose output in mice
Zhonglong Wang, Xiangfei Gong, Li Jiang, Ke Wang, Xinyuan Sun, Yingxi Li, Mengtong Ran, Yanshen Chen, Hongdong Wang, Xuehui Chu, Shun Wang, Junjie Wang, Xiao Zheng, Haiping Hao, Hao Xie
This study shows that the brainstem controls hepatic glucose metabolism through lateralized sympathetic pathways to the liver, with compensatory mechanisms after denervation.
bioRxiv · Oct 27, 2025 · PreprintNeuroscience