Haiping Hao

ChemIntelligence enables antibody-free, ultra-low-input profiling of lysine lactylation and diverse acyl-proteomes using chemical derivatization and computational methods.

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

This paper describes a thermal processing method to enhance ginger-derived extracellular vesicles for targeted oral therapy of colitis, showing improved tissue accumulation and therapeutic efficacy.

This study shows that the brainstem controls hepatic glucose metabolism through lateralized sympathetic pathways to the liver, with compensatory mechanisms after denervation.

This study shows RSV infection protects against SARS-CoV-2 by boosting γδ T cell immunity and mucosal T cell responses in mice.

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.