Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies LINC00881 as an Essential Regulator of Calcium Handling in the Cardiomyocyte
Xianghai Liao, Peter J. Kennel, Bohao Liu, Trevor R. Nash, Richard Z. Zhuang, Amandine Godier-Furnémont, Chenyi Xue, Rong Lü, P.C. Colombo, Nir Y. Uriel, Muredach P. Reilly, Steven O. Marx, Gordana Vunjak‐Novakovic, Veli Kemal Topkara
This study identifies LINC00881 as a key regulator of calcium handling in failing human hearts through DNA methylation analysis and functional studies in iPSC-derived cardiomyocytes.
JCI Insight · Jan 19, 2023Peer-reviewedGenomics