Chenyi Xue

Cytokinesis Arrest-induced Binucleation of Macrophages ProducesHighly Efficient Efferocytes

The paper shows that cytokinesis arrest in macrophages leads to binucleation, which enhances efferocytic function and reduces autoimmune responses.

IgG Propels Atherosclerosis by Noncanonically Activating Macrophages

This study identifies IgG's pro-atherogenic role through noncanonical activation of macrophages, independent of its classical function, by acting as a TLR4 ligand and promoting inflammation.

PRDM16 controls smooth muscle cell fate in atherosclerosis

This study shows PRDM16 maintains SMC identity and regulates atherosclerotic plaque composition by inhibiting synthetic gene programs during SMC fate switching.

Single-Cell Multimodal Profiling Reveals a Novel CD26+ Fibroblast Subpopulation in Atherosclerosis

The paper identifies a novel CD26+ fibroblast subpopulation in atherosclerosis using CITE-seq and shows its expansion into fibrous caps during disease progression.

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation

Single-cell multimodal profiling of atherosclerosis identifies CD200 as a lineage marker of vascular smooth muscle cells and their derived cells

The paper identifies CD200 as a specific marker for vascular smooth muscle cells and their derived cells in atherosclerosis using CITE-seq and validates it across multiple techniques.

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risks

The paper uses multimodal single-cell profiling to identify diverse monocyte subtypes and links them to cardiovascular disease risk factors.

Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies LINC00881 as an Essential Regulator of Calcium Handling in the Cardiomyocyte

This study identifies LINC00881 as a key regulator of calcium handling in failing human hearts through DNA methylation analysis and functional studies in iPSC-derived cardiomyocytes.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

ASEP: gene-based detection of allele-specific expression in a population by RNA-seq

ASEP detects gene-level allele-specific expression in populations using RNA-seq, identifying differential ASE between conditions and extending findings to cardiometabolic traits.