Author

Veli Kemal Topkara

Columbia University Irving Medical CenterORCID 0000-0002-2236-2008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron Rodriques· 1 shared Alexander N. KatchmaniD· 1 shared Amandine Godier-FurnémontiD· 1 shared Bi-Xing Chen· 1 shared Bohao LiuiD· 1 shared Chenyi XueiD· 1 shared Elaine Y. WaniD· 1 shared Gary Andrew BradshawiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Aaron Rodriques

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

Aaron Rodriques, Guoxia Liu, Alexander N. Katchman, Sergey I. Zakharov, Elaine Y. Wan, Marian Kalocsay, Robyn J. Eisert, Gary Andrew Bradshaw, Bi-Xing Chen, Lin Yang, Steven R. Reiken, Xianghai Lai, Ruiping Ji, Najla Saadallah, Veli Kemal Topkara, , Jared Kushner

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

bioRxiv · May 8, 2025 · PreprintCell Biology

Genome-Wide DNA Methylation Profiling of the Failing Human Heart with Mechanical Unloading Identifies LINC00881 as an Essential Regulator of Calcium Handling in the Cardiomyocyte

Xianghai Liao, Peter J. Kennel, Bohao Liu, Trevor R. Nash, Richard Z. Zhuang, Amandine Godier-Furnémont, Chenyi Xue, Rong Lü, P.C. Colombo, Nir Y. Uriel, Muredach P. Reilly, Steven O. Marx, Gordana Vunjak‐Novakovic, Veli Kemal Topkara

This study identifies LINC00881 as a key regulator of calcium handling in failing human hearts through DNA methylation analysis and functional studies in iPSC-derived cardiomyocytes.

JCI Insight · Jan 19, 2023Peer-reviewedGenomics