Plat safeguards maternally aged oocytes against programmed cell death through activating the Erk1/2 pathway
Xianying He, Hanwen Zhang, Ya Wang, Huanyu Yan, Qiuzhen Chen, Min Su, Qiaozhen Shi, Xiao Zeng, Wei Sheng, Yangmin Wang, Chikun Wang, Shuyue Hou, Zhibin Hu, Yuanlin He, Xi Wang
This study identifies Plat's role in protecting aged oocytes from programmed cell death by activating the Erk1/2 pathway, showing tPA supplementation improves oocyte quality.
Science China Life Sciences · Nov 13, 2025Peer-reviewedDevelopmental Biology