Xi Wang

The paper introduces DeepTrack, a lineage tracing model that combines cellular barcoding with single-cell multi-omics to study cell fate transitions and molecular changes during mammalian development.

RAFTER quantifies mRNA translation by labeling efficiently translated RNAs with an RNA editing enzyme and releasing factor, showing correlation with Ribo-seq and Polysome-seq but with a simpler workflow enabling single-cell analysis.

GALILEO autonomously discovers therapeutic peptides by combining AI reasoning with lab experiments, identifying peptides that block membrane currents and modulate immune responses.

The paper shows replication stress causes rDNA instability, leading to immunostimulatory RNA that activates RLR signaling and drives inflammation.

This study identifies Plat's role in protecting aged oocytes from programmed cell death by activating the Erk1/2 pathway, showing tPA supplementation improves oocyte quality.

This study uses EEG and artificial neural networks to analyze how metacontrol states affect conflict regulation, finding theta band activity reflects mismatch between expected bias and task demands, while alpha and beta bands are involved in neural reset.

ENCODE-rE2G, a classifier trained on K562 CRISPR perturbations, maps 13,455,443 enhancer-gene interactions across 352 biosamples, matching or exceeding prior models on CRISPR, eQTL, and GWAS benchmarks.

The paper uses a CRISPRi screen in hESC differentiation to identify enhancers with nonlinear regulatory activity, revealing a CTCF loop-constrained model for improved enhancer prediction.

This study creates a spatial proteomic atlas of lung tissues from COVID-19 victims, identifying protein dysregulations and markers of pathological changes.

Uni-RNA, a deep learning model pre-trained on a large RNA sequence corpus, is reported to lead existing methods on structural and functional prediction tasks after fine-tuning.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.

This study identifies M segment RNA splicing as a determinant of host range in influenza A virus by comparing human- and bird-adapted strains.