Histological morphometric correlates of MRI-defined cortical thinning in temporal lobe epilepsy
Joanna Bartkiewicz, Xiao Fenglai, Yau Mun Lim, Maritchka Ryniejska, Hanaa El Hachami, Alicja Mrzyglod, Joan Liu, Anna Miserocchi, Andrew W McEnvoy, John S. Duncan, Matthias J. Koepp, Maria Thom
This study investigates the histological correlates of MRI-defined cortical thinning in temporal lobe epilepsy, finding that thinning is associated with altered neuronal packing and cell-size distributions rather than neuronal loss.
bioRxiv · Oct 25, 2026 · PreprintPathology