This study investigates the histological correlates of MRI-defined cortical thinning in temporal lobe epilepsy, finding that thinning is associated with altered neuronal packing and cell-size distributions rather than neuronal loss.

bioRxiv · Oct 25, 2026 · PreprintPathology

CANVAS causing AAGGG repeat expansions cause tissue-specific reduction in RFC1 expression and increase sensitivity to DNA damage

Riccardo Curró, Natalia Dominik, Stefano Facchini, Ricardo Parolin Schnekenberg, Cecilia Perini, Riccardo Ronco, Bianca Rugginini, Arianna Ghia, Silvia Bione, Nadia Tagliaferri, Glenda Paola Grupelli, Simon A. Lowe, Amy R. Hicks, Elisa Vegezzi, Roberto Simone, , Andrea Cortese

bioRxiv · Nov 18, 2025 · PreprintNeuroscience

Molecular and cellular signatures differentiate Parkinson's disease from Parkinson's disease with dementia

Aine Fairbrother-Browne, Melissa Grant‐Peters, Jonathan Brenton, Hemanth R. Nelvagal, Regina Hertfelder Reynolds, Yau Mun Lim, Emil Karl Gustavsson, Hannah L. Macpherson, Kylie Montgomery, James R. Evans, Amy R. Hicks, Nancy Chiraki, Toby J Curless, Raquel Real, Theodoros Xenakis, , Mina Ryten

This study compares molecular and cellular signatures of Parkinson's disease and Parkinson's disease with dementia using single-nuclear transcriptomics, finding distinct gene expression patterns and biological pathways.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience