Maria Thom

This study investigates the histological correlates of MRI-defined cortical thinning in temporal lobe epilepsy, finding that thinning is associated with altered neuronal packing and cell-size distributions rather than neuronal loss.

The paper uses single-cell Mendelian randomisation to identify cell-type specific genetic effects on brain disease and behaviour, revealing 118 genes with causal associations to 16 brain phenotypes.

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

The paper compares proteomic and transcriptomic profiles of hippocampus and cortex in SUDEP and high-risk SUDEP cases, finding no proteomic differences but 55 differentially expressed genes in hippocampus.