NINTEDANIB AND PIRFENIDONE AFFECT GROWTH AND DIFFERENTIATION OF HUMAN ALVEOLAR TYPE 2 CELLS
Alexey V. Bazarov, Andrea Serra-Marques, Giulia Protti, Monica M. Yang, Ram Prasad Naikawadi, Gary A. Green, Seoyeon Lee, Jasleen Kukreja, Michael A. Matthay, Michael Wax, Xiaodan Cai, Rachel M. Wolters, Jason R. Rock, David Garfield, Paul J. Wolters
This study investigates how pirfenidone and nintedanib affect the growth and differentiation of human alveolar type 2 cells in organoid cultures, revealing differences in their impact on surfactant protein C expression and cell identity.
bioRxiv · Mar 3, 2026 · PreprintCell Biology