Engineering B cells to Express Fully Customizable Antibodies with Enhanced Fc Functions
Chun Huang, Atishay Mathur, Chan-Hua Chang, Xiaoli Huang, Hsu-Yu Chen, Zachary Davis, Karla D. O'Dell, Elizabeth A. Shuman, Raymond W. Kung, Geoffrey L. Rogers, Paula M. Cannon
This study engineers B cells to express fully customizable antibodies with enhanced Fc functions through genome editing of the immunoglobulin Heavy chain locus.
Nature Communications · May 13, 2026Peer-reviewedImmunology