Multimodal AI for Single cfDNA Profiling and Cancer Screening
Bo Wang, Liyang Song, Hefei Li, Nan Lin, Ying Xin, Xiaowen He, Wenxin Liu, Li Liu, Jian Cui, Xuesong Li, Ying Mei, Qiuting You, Haodong Zhu, Guoqiang Zhao, Guo Chen, , Yingjiang Ye
The paper develops a Transformer-based model called cfAI to profile and detect cancer-derived cfDNA by integrating methylation, fragmentomics, and histone modifications, achieving high sensitivity and specificity in multi-cancer detection.
bioRxiv · Dec 30, 2025 · PreprintBioinformatics