Jing Liu

Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity

The paper uses deep mutational scanning to study pleiotropic effects in rhodopsin, revealing how mutations impact multiple molecular phenotypes and shape light sensitivity.

Dual-Binding Scaffold RRsS1 Bridges Pol IV Transcripts and DNA Templates for Robust Reproductive siRNA Biogenesis

This study identifies RRsS1 as a dual-binding scaffold that stabilizes Pol IV transcription complexes to enhance siRNA biogenesis in plant reproduction.

Intestinal Dysbiosis in Necrotic Enteritis: Dissecting the Roles of Eimeria and Clostridium perfringens

This study investigates how Eimeria and Clostridium perfringens contribute to intestinal dysbiosis in necrotic enteritis, showing Eimeria drives dysbiosis and facilitates C. perfringens colonization.

Development of a High-throughput in vivo Assay for the Determination of Adenylation Domain Specificities

The paper develops an in vivo assay called ASCR to determine adenylation domain specificities in NRPS, testing 54 A domains from various organisms and confirming novel cyclic pentapeptides.

Therapeutic targeting inflammation linking periodontitis and atherosclerotic comorbidities using cell-free DNA-capturing nanomaterials

This study develops nanomaterials that capture cell-free DNA to reduce inflammation in periodontitis and atherosclerosis by modulating macrophage lipid markers.

Carbon dioxide sequestration into biomineral armor by ants

This study shows fungus-farming ants convert atmospheric CO2 into biomineral armor, offering a natural example of carbon sequestration that could inform climate change mitigation strategies.

Multimodal AI for Single cfDNA Profiling and Cancer Screening

The paper develops a Transformer-based model called cfAI to profile and detect cancer-derived cfDNA by integrating methylation, fragmentomics, and histone modifications, achieving high sensitivity and specificity in multi-cancer detection.

Single-Cell and Spatial Transcriptomic Analyses Reveals the Dynamic Transcript Profiles of Myocardial Lymphangiogenesis post Myocardial Infarction

This study integrates single-cell and spatial transcriptomic data from mouse hearts post-myocardial infarction to identify functionally distinct lymphatic endothelial cell subtypes and their roles in tissue repair and inflammation.

Multi-level broad-yet-sparse input organization of LC-NE neurons revealed by multiplexed whole-brain EM reconstruction

The paper maps synaptic input architecture of LC-NE neurons in larval zebrafish, revealing broad-yet-sparse input organization across brain regions.

Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

The paper identifies sphingolipids from a bacterial PKS as mediators of microbiota protection against pathogens in C. elegans.

PIB: Parallel ion beam etching of sections collected on wafer for ultra large-scale connectomics

The paper introduces a parallel ion beam etching method for thinning sections on a wafer, enabling high-resolution volumetric imaging for connectomics.

Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study Using Three Deep Learning Algorithms

The paper compares newly born orphan proteins to never born proteins using three deep learning algorithms to predict their structural properties and assess their similarity.

The regulation of mammalian maternal-to-embryonic transition by Eukaryotic translation initiation factor 4E

This study shows eIF4E is essential for the maternal-to-embryonic transition in mouse embryos, with knockout or inhibition causing developmental failure.

Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level

The paper shows neonatal LPS exposure reduces PFC ATP8A2 in mice by increasing IFN-γ, which is linked to depressive-like behaviors.

Subcellular mRNA localization and local translation of Arhgap11a in radial glial cells regulates cortical development

The paper shows that Arhgap11a mRNA localization and local translation in radial glial cells control cortical development by regulating RGC morphology and neuron positioning.

The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

This study structures and functionally characterizes the mouse RIPK3 amyloid complex in necroptosis, revealing a unique N-shaped core and a structural transformation from hetero- to homo-oligomer.

Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

Transcriptional trajectories of human kidney disease progression

The paper identifies transcriptional trajectories in human kidney disease progression using machine learning and validates findings in a mouse model.

A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

The paper presents a chemical probe collection for studying protein methyltransferases, showing their utility in modulating epigenetic marks and affecting T cell differentiation.

Altered Developmental Trajectories in Intrinsic Function between Default, Salience, and Executive Networks in High-Functioning Autism

The paper examines age-related changes in brain network connectivity in ASD and identifies distinct maturation patterns in three core networks.

Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing

Single cell RNA sequencing identifies two reprogramming branches in mouse fibroblasts, with Dppa5a marking pluripotent cells and IFN-gamma inhibiting the transition.