NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron
Xiaoyuan Lin, Zhou Sha, Chunlin Zhang, Julia Maria Adler, Ricardo Martin Vidal, Christine Langner, Beibei Fu, Yan Xiong, Meng Tan, Chen Jiang, Hao Zeng, Xiaokai Zhang, Qian Li, Jingmin Yan, Xiaoxue Lu, , Zhenglin Zhu
This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.
Nature Communications · Jul 29, 2025Peer-reviewedEvolutionary Biology