Cancer Cell Adaptation to Cycling Hypoxia: Integrating Mathematical Modeling with Experimental Validation of HIF-1 Dynamics
Xihua Qiu, Yamin Liu, Paola Vera-Nicola, Eran Agmon, Kshitiz Gupta, Yasir Suhail
The paper models and experimentally validates how HIF-1 dynamics in cycling hypoxia lead to specific gene expression patterns linked to cancer progression.
bioRxiv · Apr 6, 2025 · PreprintBioinformatics