Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates
Jillian L. Seiler, Anna Chiara Impastato, E. Zhang, Kade J Kelley, Thomas L Bennett, Bradley Studnitzer, Claudia R. Prindle, Benjamin H. Rajewski, Barry A. Badeau, Xinjian Jiang, Russell Potterfield, Jordan Y Delev, Daniel L. Marks
This study shows that activating both MC3R and MC4R in obese primates leads to weight loss and reduced food intake, with a new dual agonist peptide showing efficacy and safety.
bioRxiv · Nov 25, 2025 · PreprintNeuroscience