Modeling Post-Gastrula Development via Bidirectional Pluripotent Stem Cells
Kuisheng Liu, Zihui Yan, Dandan Bai, Rui Jiang, Yan Bi, Xiangjun Ma, Jiani Xiang, Yifan Sheng, Baoxing Dong, Zhiyuan Ning, Shanru Yi, Yingdong Liu, Xinyi Lei, Yanping Jia, Yan Zhang, , Wenqiang Liu
This study develops bidirectional pluripotent stem cells (BPSCs) capable of generating both trophoblast and epiblast lineages, enabling the recapitulation of post-gastrula development in vitro and in vivo.
Cell Research · Aug 29, 2025Peer-reviewedDevelopmental Biology